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Quality control interview Questions:

Pharmacy tech interview questions


Q52-. What is room temperature?

Ans) 25-degree centigrade

Q53-.  What is the Ultraviolet(UV) and visible spectroscopy range?

Ans) UV spectroscopy range 200-400 nm, Visible spectroscopy range 400 nm to 800nm.

Q54-) What is the use of UV Spectroscopy?

Ans) Spectroscopy used for detecting the functional groups, impurities. Qualitative and quantitative analysis can be done.

 Q55-) What is the difference between qualitative and quantitative analysis?

Ans) Qualitative analysis involves the identification of the compound or chemical-based on their chemical(absorption, emission )or physical properties(e.g Melting point, boiling point).

 Quantitative analysis involves the estimation or determination of concentration or amount of the chemical compounds or components.


 Q56-) Explain the principle of Ultraviolet spectroscopy?

Ans) UV spectroscopy uses light in the UV part of the electromagnetic spectrum. UV absorption spectra arise in which molecule or atoms outer electrons absorb energy, undergoes a transition from lower energy level to higher energy level. For each molecule, absorbance at wavelength is specific.

Q57-) Explain about Beer Lambert's law?

Ans) It states that the intensity of monochromatic light absorbed by a substance dissolved in a fully transmitting solvent is directly proportional to the substance concentration and the path length of the light through the solution.

Q58-)  Explain the Infrared spectroscopy principle?

Ans) When a molecule absorbs the Infrared radiation, it vibrates and gives rise to packed Infrared(IR) absorption spectrum. This IR spectrum is specific for every different molecule absorbing the IR radiation, useful for its identification.


 Q59-) What is the body temperature?

Ans) 37 oCelsius or 98.6 oF

Q60-) Define pH? What is the pH of blood?

 Ans) pH -Negative logarithm of hydrogen ion concentration. Blood pH-7.35 to 7.45.

Q61-) Expand LCMS, HPLC, UPLC, TLC, and GC?

Ans)

  •  LCMS- Liquid Chromatography
  • HPLC- High-Performance Liquid Chromatography,
  • UPLC- Ultra-High-Performance Liquid Chromatography,
  • TLC- Thin Layer Chromatography,
  • GC- Gas Chromatography.


Q62-) What is the HPLC principle?

Ans)

  •  It is a technique used for separating the mixture of components into individual components based on adsorption, partition, ion exchange and size exclusion principles. Stationary phase and mobile phase used in it.  HPLC used for identification, quantification, and purification of components forms a mixture.


Q63-) Explain HPLC instrumentation?

Ans)

  •  It involves solvent system, pump, Sample injector, HPLC columns, Detectors, and Recorder. Firstly, the solvent(mobile phase) is degassed for eliminating the bubbles. It is passed through the pump with uniform pressure. The liquid sample is injected into the mobile phase flow stream. It passes through the stationary phase identified by the detectors and recorded.


Q64-) In reverse phase HPLC, which type of stationary phase is used and give an example?

Ans) Non-polar stationary phase used

Ex: Silica gel C-18

Q65-) What are the detectors used in HPLC?

Ans)
  •  UV detector, IR detector, Fluorescence detector, Mass spectroscopy, LC MS etc.
  • Q66-) How to calculate Retention factor in paper chromatography?
  • Ans) Rf = Distance traveled by solute/ Distance traveled by the solvent.


Q67-) Define molarity?

Ans) Number of moles of solute per liter solution. Denoted with M

Q68-) Define Molality?

Ans) Number of moles of solute per kilogram solvent. Denoted with m

Q69-) Define Normality?

Ans) Number of Number of moles equivalent per liter solution.

Q70-) Molecular weight of oxygen?

Ans) 16

Q71-)  Difference between humidity and relative humidity?

Ans)

  • Humidity  Measure of the amount of water vapor present in the atmosphere.


  • Relative humidity- Water vapor amount exists in air expressed as a percentage of the amount needed for saturation at the same temperature.


Q72--Acceptance Limit for Friability of tablets?
Ans)

  •  Acceptable tablets weight loss is 0.5 to 1.0% for 100 revolutions. Or 1-5% weight loss for 10 minutes revolution. ( Generally, 6 grams of weighed and de-dusted tablets place in the rotating apparatus, it revolves at a speed of 25 revolutions per minute i.e 25 rpm. Tablets freely fall from 6-inch height for every rotation. These tablets subjected to 100 rotations or for 10 minutes i.e 250 rotations (10 min*25rpm)).


Q73--Acceptance limit for uniformity of content of tablets?


Ans) There are two criteria for acceptance limit.


  • Take 30 randomly selected tablets. Take 10 tablets, and assay individually. 9 out of 10 tablets should be in the range of 85% to 115%. One tablet can be in the range of 75%-125%. If this criterion fits, it passes the test. If these conditions not met, remaining 20 tablets should be assayed. All of the 20 tablets should in the range of 85% to 115%.


Q74-What are different types of capsule sizes and holding the capacity of smallest and largest size?

 Ans) Sizes are 000, 00 , 0, 1, 2, 3, 4, 5.


  • Smallest size 5, It can hold at least 65 mg of the drug.
  • Largest size 000, It can hold up to 1000 mg of the drug.


Q75--What are the types of Gas Chromatography?

Ans) Two types available.


  • Gas-Solid chromatography(GSC): Stationary phase is solid and the gas used as mobile phase.
  • Gas-Liquid chromatography(GLC): Liquid on thin solid support used as stationary phase and gas used as mobile phase.


Q76--Which material used as the stationary phase and mobile phase in GSC and GLC?
Ans)

  • Granular silica, alumina or carbon used as stationary in phase in GSC. Non-volatile liquid on a solid base like Diatomaceous earth or kieselguhr used as stationary phase in GLC. Inert gases like helium or nitrogen used as mobile phase(carrier gas) in both GSC and GLC.


Q77--which type of tablets does not require Disintegration test?

Ans) Sustained-release tablets, Delayed released tablets and Chewable tablets.

Q78--What is disintegration time for Uncoated, coated, enteric-coated, dispersible and soluble tablets?

Ans) Uncoated tablets  30 min (Uses water as a medium at 37+20C temperature)
  • Coated tablets- 30 min (Uses water as a medium at 37+20C temperature) 
  • Enteric Coated tablets- 60 min (Uses mixed phosphate buffer at 37+20C temperature) or It should no disintegration for 2 hours (Using in 0.1N Hcl as a medium at 37+20C temperature)
  • Dispersible tablets  3 min (Uses water as a medium at 19 to 210C temperature)
  • Dispersible tablets  3 min (Uses water as a medium at 19 to 210C temperature)


Q79-What is disintegration time for soft gelatin and Hard gelatin capsules?
Ans)


  • Soft gelatin capsules- 60 min (Uses water as a medium at 210C temperature)
  • Hard gelatin capsules  30 min (Uses water as a medium at 210C temperature)


Q80-Accuracy VS Precision:

  • Accuracy also is known as trueness. Analytical Procedure accuracy is the closeness between the accepted reference value or conventional true value and the result value. One measurement is enough to determine the accuracy of an analytical procedure. It does not tell about the quality.
  • For accepted reference value is 20, your result value is 19.9 or 20.1. Then it is said as high accuracy.
  • In the same case, your result value is 18.7 0r 21.4. Then it is stated as low accuracy.



  • Precision: Analytical Procedure precision is the closeness between several measurements taken from the homogenous sample multiple samplings under specified conditions. To measure the precision of an analytical procedure requires several measurements. It speaks about quality.

Forex: From a homogenous sample, you have measured multiple samples, the values you obtain is

 A. 19.2, 19.4, 19.3, 19.2, 19.1

 B. 10.2, 10.4, 10.3, 10.2, 10.1

 C. 19.2, 22.4, 16.6, 17.1, 16.9

In the above options, Result A& B said as High precision, Result C said as Low precision. Here the consideration is a series of measurement values for a particular homogenous sample. There is no reference value in the concept of precision.

Q81--Differentiate between relative humidity and absolute humidity?
Ans)

  • Absolute humidity also called as Humidity. Simply defined as the amount of water vapor (moisture) present in a volume of air. Unit expressed as gram/m3.



  • Relative humidity: Relative nothing but comparison or ratio. So it is expressed in percentage(%). It is the ratio of air current water vapor/moisture/humidity to highest possible water vapor/moisture/ humidity. This highest possible humidity depends upon the current specific air temperature.


Ex: Current air contains 1 gram/m3 of water vapor (humidity), For that air, it can hold up to 4 gram/m3 of water vapor (humidity) (It depends on temperature).

 Relative humidity = *100 = 25%

Q82--LOD:


  • Limit of Detection: Also known as Detection Limit. For a particular analytical procedure, Upto how much the lowest amount of component or analyte in a sample can be detected. That is the detection limit for that individual or particular analytical procedure. It does not mean that it should able to quantitate that analyte.  It should able to detect that analyte, that's it.
  • Q83-LOQ: Limit of Quantitation: Also known as Quantitation Limit. For a particular analytical procedure, up to how much lowest of analyte in the sample can be quantitated with suitable accuracy and precision. LOQ come into picture in quantitative assays to determine the degraded products or impurities in the samples.


Q84- What Is The Responsibility Of A Pharmacist?

Answer :

 The responsibility of a pharmacist is to


  • Manage a drug store
  • Advising patients and physicians
  • Verifying the accuracy of the prescription
  • Reviewing possible side effects
  • Assigning correct dosage
  • Recommending most appropriate non-prescription drug
  • Give information to the patient about drug interaction

Q85-. What Are The Three Qualities A Professional Pharmacist Should Have?

Answer :


  • Drug Management
  • Customer Management
  • Staff Management
  • Medical Terminology(Adaptive*) Interview Questions

Q86- What Are The Record-Keeping Procedures That A Pharmacist Have To Do?

Answer :

 The record-keeping procedures that a pharmacist have to do


  • Storing pharmacy files
  • Patient records
  • Inventories and update system files
  • Registries of poisons and controlled drugs

Q87-. What Are The Side Effects Of Methadone?

Answer :

The side effects of methadone are:


  • Feeling anxious, nervous or restless
  • Insomnia ( Sleeping disorder )
  • Feeling drowsy and weak
  • Nausea, vomiting, diarrhea, constipation, loss of appetite, dry mouth
  • Impotence
  • Medical Terminology(Adaptive*) Tutorial

Q88. Classify The Controlled Drug? What Is The Storage Procedure For Controlled Drug?

Answer :


  • The controlled drug is classified into five, Schedule type 1, Schedule type 2, Schedule type 3, Schedule type 4 and Schedule 5.



  • For CD drug, it should be stored into a closed cabinet made up of metal and with a lock on it.  Moreover, only authorized personnel should have access to it and only he can administer the CD drug to the patient.  For home visit doctor should carry in a lockable bag.Pharmacist.


Pharmacology Interview Questions

Q89-. Is Pharmacist Allowed To Give A Copy Of Prescription?

Answer :


  • Yes, the pharmacist is allowed to give a copy of prescription but they can only use a copy of the prescription for an informational purpose.   A pharmacist cannot dispense a drug from a copy of a prescription. They can contact your doctor to provide you with a new prescription in case you lost your prescription based on the information on the Copy of prescription.



Q90-. What Are The Errors That A Pharmacist Should Avoid While Dispensing Drug?

Answer :


  • Patients wrong information (age, weight, allergies, pregnancy status, etc.)
  • Inaccurate drug information
  • Miscommunication between health professionals, staff and patient
  • Wrong drug labeling, packaging, and nomenclature ( lookalike drug or package)
  • Inadequate education is given to staff related to drugs
  • Inappropriate way of storage, standardization, and distribution of drugs
  • Ignoring quality processes and risk management
  • Inappropriate way of medication delivery device acquisition
  • Pharmacology Tutorial  Clinical Research Interview Questions

Q91-. What Are Warfarin And What Are Some Of The Drugs It Interacts And Should Be Avoided?

Answer :


  • Warfarin is a drug used as anti-coagulant, and it is used in a patient who is at high risk of a heart attack due to a blood clot.


Some of the drugs with which it interacts and should be avoided in combination with


  • Aspirin
  • Clopidogrel
  • Danaproid
  • Dipyridamole
  • LMWHs
  • NSAIDs
  • Ticlopidine
  • Unfractionated heparin


 Q92-. What Are The Problems You Face Being A Pharmacist?

Answer :

  • Being unable to read prescription
  • Administrating control drug and dealing with patient
  • Need to communicate with all type of people
  • To see drug interaction with prescribed drugs
  • Medical Cardiology Interview Questions
Q93-. Explain Why Doctor Prescribes Antibiotics More For Viral Infection Instead Of Anti-viral Drugs?

Answer :


  • Doctors prescribe antibiotics without any test because the most infectious disease is caused by antibiotics, though antibiotics are less effective on viral infection, at the same time it has fewer side-effects and more spectrum compare to anti-viral. Anti-viral has a narrow spectrum, which means it is effective in the limited virus.  In serious condition, only anti-viral is prescribed.


Q94-. What Is Nabp?

Answer :


  • NABP is the Electronic Licensure Transfer Program allows licensed pharmacists to transfer their existing pharmacist license easily from one state to another.


Pharmaceutical Quality Assurance Interview Questions

Q95- What Are The Information Should Be There On A Prescription For Controlled Drugs?

Answer :

For a controlled drug prescription should cover all this information:


  • Date of Issue
  • Patient name and address
  • Practitioner name, address and DEA registration number
  • Drug name
  • Drug strength
  • Dosage form
  • Quantity prescribed
  • Directions for use
  • Number of refills authorized
  • Manual signature of the prescriber


Q96-. Explain Can Controlled Substance Prescription Be Refilled?

Answer :


  • Controlled substance prescription can be refilled for up to five times in six months, schedule type V can be refilled as directed by a physician, while type II cannot be refilled.


Q97- Is It Permissible For Controlled Drug To Dispense A Prescription For A Quantity Less Than The Face Amount?

Answer :


  • Yes, partial refill of schedules III and IV controlled substance prescriptions are accepted under federal regulations provided that partial filling is dispensed and recorded in the same manner as a refilling, the total quantity dispensed in all partial filling does not exceed the total quantity prescribed, no dispensing occurs after six months past the date of issue.



Q98- Explain How Pharmacist Can Help The Patient With Asthma?

Answer :

The pharmacist can help the patient with Asthma by educating them and give information on it


  • Trigger management
  • Role of controller medications
  • Role of Rescue medications
  • Early detection of disease
  • Medical School Interview Questions

Q16. Explain What Is Peak Flow Meter?

Answer :


  • The peak flow meter is a cheap device used for assessing a patient's current asthma control.  It helps the patient to monitor the Asthma level and its severity.  It measures the peak expiratory flow (PEF) rate.


Q99- Can Pharmacies Provide Ec (emergency Contraceptive) To Women Under 17 Years Old?

Answer :


  • Yes, pharmacies can dispense EC to women under 17 years old, it can be sold directly on store shelves without a prescription.


Paramedic Interview Questions

Q100- Explain How You Process Your Prescription?

Answer :

Once the patient prescription is processed, we follow the following steps:


  • Prescription Drop off: Once the prescription is received, immediate communication begins with the doctor and insurance company, to make sure that we have the required authorization to dispense the medicine.



  • Benefits Investigation: With specialty prescription, we take additional steps and information to understand the benefit and work with patient insurance plan and doctor to get him on therapy as soon as possible



  • Prescription Pickup: If a patient is waiting for a prescription to be authorized, we will call to schedule a pickup at a target that is convenient for the patient






Click here to see Pharmacy tech interview questions and answers for fresher: Part-1











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